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Hypoactive Sensual Desire Disorder (HSDD) is a common sensual dysfunction in women, characterized by a persistent or recurrent deficiency or absence of sensual fantasies or desire for sensual activity. The prevalence of HSDD is approximately 10-15% in women of all ages. The condition can significantly affect the quality of life and lead to relationship problems. In recent years, several medications have been developed to treat HSDD, including Flibanserin 100mg, also known as Fili 100.
Fili 100mg - A Brief Overview:
Fili 100mg is a medication approved by the FDA for treating HSDD in premenopausal women. It is a non-hormonal, selective serotonin receptor agonist and antagonist. The medication is also known by its brand name Addyi. Fili 100 works by increasing dopamine and norepinephrine levels while decreasing the serotonin level in the brain. These neurotransmitters are responsible for regulating mood, pleasure, and sensual desire.
Fili 100mg was first approved by the FDA in 2015 after several clinical trials. The medication is available in the form of oral tablets and is only available with a prescription from a licensed healthcare provider.
How Fili 100mg Works:
Fili 100 works by targeting neurotransmitters in the brain that are responsible for regulating sensual desire. The medication acts on the serotonin receptors, increasing dopamine and norepinephrine levels while decreasing the serotonin level in the brain. It leads to an increase in sensual desire and arousal.
Dopamine is a neurotransmitter accountable for handling amusement, motivation, and reward. Norepinephrine is a hormone that increases heart rate, blood pressure, and arousal. Serotonin is a neurotransmitter that regulates mood, appetite, and sensual function. By increasing dopamine and norepinephrine levels while decreasing serotonin levels, Fili 100mg can increase sensual desire and arousal.
Dosage and Administration:
Fili 100 is available as oral tablets taken once a day at bedtime. The recommended starting dose is 100mg per day, taken orally, and it should be taken at bedtime to minimize the risk of adverse effects. The medication should be taken with water and without food, as taking it with food can reduce its efficacy.
The dose may be increased to a maximum of 200mg per day, but only after 4 weeks of treatment and if the initial dose of 100mg is well-tolerated. It is important to note that the higher dose is associated with an increased risk of adverse effects, including dizziness, somnolence, and hypotension. The maximum customary amount should not be surpassed.
Flibanserin 100mg should be taken daily to achieve maximum benefit. If a dose is skipped, it should be ingested as soon as feasible unless it is close to the time for the following dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. It is important not to take a double dose to compensate for a missed dose.
Precautions and Contraindications:
Fili 100mg is contraindicated in women who are pregnant or breastfeeding. The medication should not be taken by women who have liver problems, alcohol use disorder, or are taking medications that interact with Fili 100.
Women with liver impairment should use Fili 100mg cautiously, as it can increase the risk of adverse effects. The medication should also be used with caution in women with renal impairment. Women with moderate or severe hepatic impairment should not take Fili 100.
Fili 100 should not be taken with alcohol, as it can increase the risk of adverse effects, including hypotension, syncope, and sedation. The medication should not be taken with grapefruit or grapefruit juice, as it can increase the levels of Fili 100mg in the blood, leading to an increased risk of adverse effects.
Fili 100 should be used cautiously in women with a history of depression, bipolar disorder, or other mental health disorders. Women who experience any mood changes while taking the medication should contact their healthcare provider immediately.